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Arimidex® (anastrozole)

Arimidex® (generic name is anastrozole) is a newer drug developed for the treatment of advanced breast cancer in women. It is manufactured by Zenica Pharmaceuticals and was approved for use in the United States at the end of December 1995. Specifically, Arimidex is the first in a new class of third-generation selective oral aromatase inhibitors.. It acts by blocking the enzyme aromatase, subsequently blocking the production of estrogen. Since many forms of breast cancer cells are stimulated by estrogen, it is hoped that by reducing amounts of estrogen in the body the progression of such a disease can be halted. This is the basic premise behind Nolvadex, except this drug blocks the action and not production of estrogen. The effects of Arimidex can be quite dramatic to say the least. A daily dose of one tablet (1 mg) can produce estrogen suppression greater than 80 % in treated patients. With the powerful effect this drug has on hormone levels, it is only to be used (clinically) by post-menopausal women whose disease has progressed following treatment with Nolvadex (tamoxifen citrate). Side effects like hot flushes and hair thinning can be present, and would no doubt be much more severe in pre-menopausal patients.

For the steroid using male athlete, Arimidex shows great potential. Up to this point, drugs like Nolvadex and Proviron have been our weapons against excess estrogen. These drugs, especially in combination, do prove quite effective. But Arimidex appears able to do the job much more efficiently, and with less hassle. A single tablet daily (1 mg), the same dose use clinically, seems to be all one needs for an exceptional effect (some even report excellent results with only 0.25 mg daily). When used with strong, readily aromatizing androgens such as Dianabol or testosterone, gynecomastia and water retention can be effectively blocked. In combination with Propecia (finasteride), we have a great advance. With the one drug halting estrogen conversion and the other blocking 5-alpha reduction , related side effects can be effectively minimized. Here the strong androgen testosterone could theoretically provide incredible muscular growth, while at the same time being as tolerable as nandrolone. Additionally the quality of the muscle should be greater, the athlete appearing harder and much more defined without holding excess water.

How should I take Arimidex?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label. Arimidex is usually taken once per day. You may need to keep taking take this medication for up to 5 years. Follow your doctor's instructions. Store Arimidex at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include stomach pain, nausea, vomiting, or blood in your stools.

Superior tolerability

• Completed 9-year tolerability profile superior to tamoxifen
• Fewer treatment related adverse events than tamoxifen
• Known, predictable and manageable safety profile
• The most mature data and most complete risk:benefit profile for an AI

Only ARIMIDEX has fewer treatment-related adverse events compared with tamoxifen including significantly fewer adverse events leading to withdrawal

ARIMIDEX is now established as a more effective and better tolerated treatment than tamoxifen in the primary adjuvant therapy of postmenopausal women with hormone-sensitive early breast cancer, given for the first 5 years following surgery when the risk of recurrence is at its highest.

ARIMIDEX is a proven choice for postmenopausal women with advanced breast cancer:

First-line:

• Significant efficacy and tolerability benefits over tamoxifen
• Tamoxifen can produce a clinical benefit following ARIMIDEX

Second-line:

• ARIMIDEX is the only aromatase inhibitor with mature survival benefit over megestrol acetate